C7344
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C7344
Sigma
Cyclic adenosine diphosphate-ribose
≥90% (HPLC), lyophilized powder
| Synonym: | ADP-cyclo[N1:1′′]-ribose, cADP-ribose, cADPR, Cyclic ADPR |
| CAS Number: | 119340-53-3 |
| Linear Formula: | C15H21N5O13P2 |
| Molecular Weight: | 541.30 |
| MDL number: | MFCD00214262 |
Description
| Biochem/physiol Actions | Mobilizes intracellular Ca2+; regulates Ca2+-induced Ca2+ release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants. |
| Packaging | Package size based on nucleotide content. |
| Physical form | Lyophilized powder containing approx. 30% sodium phosphate buffer salts. |
Properties
| assay | ≥90% (HPLC) |
| form | lyophilized powder |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
References
| reference | Lee, H.C., et al., Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity. J. Biol. Chem. 264, 1608-1615, (1989) Abstract |
| Takasawa, S., et al., Cyclic ADP-ribose in insulin secretion from pancreatic beta cells. Science 259, 370-373, (1993) Abstract | |
| Wu, Y., et al., Abscisic acid signaling through cyclic ADP-ribose in plants. Science 278, 2126-2130, (1997) Abstract |
